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In the present study, our results showed that MSC-EXO administration could significantly reduce the right ventricular systolic pressure (RVSP) and RVHI, suppress the pulmonary vascular remodeling and the endothelialmesenchymal transition (EndMT) process. Our results provided the firm information for a new method in treatment of PH, the mechanism may be may be related with the inhibition of vascular remodeling and EndMT. Our results provided the firm information for a new method in treatment of PH, the mechanism may be may be related with