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Additionally, in vitro experiments showed that LOLE enhanced the expression of HO-1 in RAW264.7 macrophages. Collectively, the aforementioned findings indicated that LOLE exerted an ameliorative effect on inflammatory response in airway of ALI mice.Various microorganisms reside in the human vagina, and the vaginal microbiome is closely linked to both vaginal and general health. For this reason, microbiome studies of the vagina have been conducted. In this study, we analyzed the vaginal microbiome of women before and after menopause to f