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Polygenic risk scores (PRSs) for mental disorders have become a major player in child psychiatry research. PRSs quantify a child's risk for childhood psychiatric disorders by summing the effects of a multitude of common risk genetic variants across the entire genome. Each genetic variant in isolation contributes a minuscule amount to the disorder, but their combined effect can be substantial. The study by Pat et al.1 illustrates how PRSs can be used as a starting point to examine the mechanisms that might link common genetic variant risk
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