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These findings in this study have major implications for the understanding of C15ORF41 and Codanin-1 function and CDA-I. Copyright 2020 The Author(s).BACKGROUND Bladder cancer is the 9th most-common cause of cancer worldwide and it is associated with high morbidity and mortality. TMB is an emerging biomarker in cancer characterized by microsatellite instability. TMB has been described as a powerful predictor of tumor behavior and response to immunotherapy. METHODS A total of 443 bladder cancer samples obtained from TCGA were analyzed for