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Emerging evidence suggests that cartilage intermediate layer protein 1 (CILP-1) is associated with myocardial remodelling. However, the prognostic value of circulating CILP-1 in patients with heart failure (HF) remains to be elucidated. This study aimed to investigate whether circulating CILP-1 can independently predict the outcome of chronic HF. This prospective cohort study included 210 patients with chronic HF and left ventricular ejection fraction 50% between September 2018 and December 2019. The primary endpoint was 1year all-