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Lastly, we discuss the possible molecular targets and the current status of drug candidates for sarcopenia treatment. In conclusion, the development of experimental models for sarcopenia is essential to discover molecular targets that are valuable as biochemical biomarkers and/or therapeutic targets for sarcopenia.Pre-stressed bolted joints are widely used in civil structures and industries. The tightening force of a bolt is crucial to the reliability of the joint connection. Loosening or over-tightening of a bolt may lead to connecto