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After this effect, MIA40 is reoxidized because of the sulfhydryl oxidase ALR, which couples disulfide formation by this machinery into the task of this breathing chain. In this review, we'll talk about the import of IMS proteins with a focus on current findings showing the diversity of disulfide relay substrates, describing the cytosolic control of this import system and highlighting the physiological relevance of this disulfide relay equipment in higher eukaryotes.Biogen