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Exosomal circ‑HMGCS1 was increased in the serums and cells of colon cancer patients. Circ‑HMGCS1 was downregulated by sevoflurane treatment in colon cancer cells and circ‑HMGCS1 overexpression could restore the effect of sevoflurane on colon cancer cell development. miR‑34a‑5p was a target of circ‑HMGCS1 and miR‑34a‑5p inhibition reversed the effect of circ‑HMGCS1 silencing on colon cancer cell progression. Moreover, circ‑HMGCS1 knockdown suppressed SGPP1 expression via sponging miR‑34a‑5p. Knockdown of circ‑HMGCS1 blocked tumor growth in
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