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Interaction device of duphaston (DPH) over graphene (G), carboxyl replaced graphene (COG) and doped COG-X (X = O/S/N/ were investigated. We studied various spectroscopic properties of adsorbed DPH with nanoclusters. To examine effect adsorption of DPH with nanoclusters, the adsorption energies were measured. To track DPH, surface enhanced Raman scattering can be used as it is a simple yet effective way of vibrational spectroscopy. The DPH recognition ended up being i