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Hyperlinks between hyperglycemia-induced oxidative stress and NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation have now been reported within the pathogenesis of diabetic issues. The present research aimed to elucidate the contribution of NLRP3-mediated apoptotic/pyroptotic neuronal mobile death to diabetes-associated despair. We found that depressive-like behavior in streptozotocin (STZ)-induced diabetic mice ended up being connected with hippocampal NLRP3 inflamm