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The upregulation of a group of ribosome/RNA polymerase genes and a cluster of genetics involving energy metabolic rate at transcriptomic amount stood out for improved creation of recombinant protein under SMG. The protein folding modulators such chaperones had been upregulated at proteomic amount, which could be a result of the increased activity of protein synthesis and may help recombinant protein production. Protein export was also enhanced, that has been revealed