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Recently, Chetail (Journal of Memory and Language, 202 has claimed there is no strong evidence that multi-letter graphemes are used in reading tasks with proficient adult readers, with most studies being statistically weak or having confounds in the stimuli used. Here, I used Monte Carlo simulation with data from reading mega-studies to examine the extent to which the number of multi-letter graphemes matters in words when letter length is held constant. This was done by simulating thousands of experiments using different sets of items