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as observed in the HCC group with a median (interquartile range) frequency of 15.82 (0-78.88) vs 0 (0- in the other groups (P less then 0.05 vs CHB group). Conclusion The differentially conserved HBC and HBV core protein regions and the P79Q substitution could be involved in disease progression. The hyper-conserved regions detected could be targets for future therapeutic and diagnostic strategies.Background Circulating microRNAs (miRNAs) are potential biomarkers for many diseases. However, they can originate from non-disease specific