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The three-layer CNN trained with labeled data generated by our proposed labeling strategy predicts human observer performance better than conventional model observers for different noise structures in CBCT images. This network also shows good correlation with human observer performance for general tasks when training and testing images have different noise structures.The coronavirus disease 2019 (COVID-19) is now a global pandemic. Tens of millions of people have been confirmed with infection, and also more people are suspected. Chest c
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