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Purpose Participatory design (PD) is a collective creative design process involving designers and nondesigners. There is limited reporting on the experience of using PD for adolescent and young adult (AYA) care. This study summarizes lessons from employing PD to develop care for AYAs with cancer. Methods A qualitative multiple-case study method was conducted of three PD processes addressing food (FfC), intimacy and sexuality (IS), and integrative medicine (IM) in caring for AYAs with cancer. Results Local key stakeholders, who were