https://www.selleckchem.com/pr....oducts/mi-773-sar405
0001) with a concomitant increase in the levels of IRS-1(P less then 0.0001), p-IRS1-1Tyr632 (P = 0.0014), Akt (P less then 0.0001), p-AktSer473/Thr308 (P = 0.0006; P less then 0.0001), AS160 and p-AS160Thr642 (P less then 0.0001) compared with type-2 diabetic rats. In Silico analysis was also performed and it showed that SIT possesses the greater binding affinity with β-arrestin-2, c-Src, and IRS-1 as well as Akt proteins and proved to attenuate insulin resistance as this study coincides with in vivo findings. Our present stud
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