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CONCLUSION Our observations indicate that the underestimation of time may occur in patients with Tourette's syndrome who receive antipsychotic drugs with high DA D2 receptor blocking potency. This may support the concept that the estimation of time is influenced by DA activity. © 2020 The Authors. Neuropsychopharmacology Reports published by John Wiley Sons Australia, Ltd on behalf of the Japanese Society of NeuropsychoPharmacology.The release of metal ions may play an important role in toxicity of metal-based nanoparticles. In th