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CONCLUSON It is concluded that macadamia nuts oil in nanocream dosage form has better antiaging activity on the skin compared to conventional cream and macadamia nuts oil can be used as an effective skin anti-aging dosage form. Copyright © 2019 Tengku Ismanelly Hanum, Lia Laila, Sumaiyah Sumaiyah, Elvi Syahrina.BACKGROUND Chemometric can be defined as a branch of analytical chemistry using statistical principles to design and select optimal analytical procedures and experiments. The chemometric technique that applies in the design of