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The biological mechanism of Dupuytren's contracture needs to be further studied in order to minimize postoperative recurrence and provide a pathological basis for the development of new therapeutic targets. HE staining, immunohistochemistry, PCR and western blotting were performed in pathological palmar aponeurosis specimens and normal palmar aponeurosis tissues for comparative study. (1) TNF-α expression was up-regulated TNF-α mRNA was more highly expressed in the pathological tissues of DD patients than in the CT group, P 0.05, an
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