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Anesthesia with deep neuromuscular block for laparoscopic surgery may result in less postoperative pain with lower intra-abdominal pressure. However, results in the existing literature are controversial. The study aimed to evaluate the effect of deep neuromuscular block on postoperative pain at rest and during coughing after laparoscopic colorectal surgery. The design is a parallel-group, randomized clinical trial. The study was conducted at a tertiary care center. Patients undergoing laparoscopic resection of colorectal tumors were inclu