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Histopathological changes seen in murine hypopharyngeal mucosa confronted with acidic bile had been preceded because of the overexpression of Tnf, Il6, Bcl2, Egfr, Rela, Stat3, additionally the deregulation of miR-21, miR-155, miR-192, miR-34a, miR-375, and miR-451a. This is the very first research to document that acidic bile is carcinogenic in the upper aerodigestive region. We indicated that oxidative DNA-damage produced by acidic bile in conjunction with NF-κB-related anti
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