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There is an exponential growth in the numbers of procedures requiring large-bore access. InSeal vascular closure device (VCD) is a novel device that seals the puncture with a biodegradable membrane, which is supported by a self-expanding nitinol frame. The current study suggests that the InSeal VCD is safe and effective in achieving hemostasis after transcatheter aortic valve replacement.Transfemoral (TF) transcatheter aortic valve replacement (TAVR) has evolved dramatically. Improvements in technique, devices, operator's experience, a