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Intervention of 8-ol significantly reduced the release of IL-1α and IL-1β and protected against caspase-11-mediated organ injury and lethality in endotoxemic mice. Thus, this study clearly suggests that the HMGB1-caspase-11 pathway is a potential drug target in lethal immune disorders and might open a new avenue in the treatment of sepsis.[This corrects the article DOI 10.3389/fphar.2020.00106.].The transient receptor potential vanilloid type 1 (TRPV1) channel is a non-selective cation channel expressed with transient receptor potentia
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