https://www.selleckchem.com/pr....oducts/GSK1904529A.h
40 ± 1.12 mM, 17.4 ± 2.20 mM and 10.4 ± 1.37 mM, respectively. To the best of our knowledge, their dual molecular mechanisms against Topo I have been discussed here for the first time (1) stabilization of Topo I-DNA complex and (2) inhibition or blocking of Topo I binding to DNA. Matrine, cytisine, and sophoridine from S. alopecuroides L. were defined as the active components group with Topo I inhibitory activity and their pharmacological mechanism was confirmed, which provided an important base for further research and development
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