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Calcium oxalate stones are the most common cause of nephrolithiasis in the United States. Smaller studies of 15 patients investigating ezetimibe, a selective cholesterol absorption inhibitor, have suggested increased urine oxalate levels with use of the drug. We attempt to better define this relationship of ezetimibe on urinary oxalate using a larger patient sample analysing multiple urine collections on and off treatment. We retrospectively reviewed all consecutive patients from 01/2018 through 04/2019 evaluated for nephrolithiasis