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can Society for Microbiology.Nuclear import of viral genomes is an important step during the life cycle of adenoviruses (AdV), requiring soluble cellular factors as well as proteins of the nuclear pore complex (NPC). We addressed the role of the cytoplasmic nucleoporin Nup358 during adenoviral genome delivery by performing depletion/reconstitution experiments and time resolved quantification of adenoviral genome import. Nup358-depleted cells displayed reduced nuclear import efficiencies of adenoviral genomes and the nuclear import recepto
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