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Bax and Bak, two functionally similar, pro-apoptotic proteins associated with Bcl-2 household, tend to be referred to as gateway to apoptosis for their prerequisite roles as effectors of mitochondrial external membrane permeabilization (MOMP), an important step during mitochondria-dependent apoptosis. The device of exactly how cells turn Bax/Bak from inert particles into fully energetic and life-threatening effecto