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The elution condition, like the pH price, formic acid percentage and ACN percentage for the eluent has also been optimized for the specified SPE performance. Underneath the enhanced condition, COPTPBA-BPDA@SA unveiled better purification overall performance than COPTPBA-BPDA without sulfonating. The LODs for ß2-receptor agonists had been within the selection of 0.08-0.22 μg/kg, in addition to recoveries in various samples at three spiked amounts (0.4, 4.0, 8.0 μg/kg) h