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Non-invasive examination revealed new onset bradycardia and PE. Such clinical manifestations were associated with targeted therapy-related CV toxicity, on which the emerging discipline cardio-oncology focused, and a multidisciplinary investigation and treatment was conducted. This case highlights the CV adverse events of novel therapies and the current challenges to be tackled in cardio-oncology. This case highlights the CV adverse events of novel therapies and the current challenges to be tackled in cardio-oncology. To evaluate the heal