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The pandemic of coronavirus disease 2019 (COVID-19) has become a global health crisis with the death toll of over 14 million people. So far, there are limited options to treat COVID-19. Remdesivir was granted emergency use authorization earlier, and full use recently. Remdesivir was originally developed against Ebola viral infection and has since been shown to exert a broad antiviral activity against as many as seven viral families [1]. On the other hand, serious adverse events and mortality remained high even with remdesivir among COVID