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0%) but the lowest specificity (62.0%). At least 2 out of 3 signs positive strategies showed 80.0% sensitivity and 94.3% specificity. All 3 signs positive strategies had the lowest sensitivity (46.7%) and the highest specificity (100.0%). The cutoff point of this revealed an area under the curve of 0.85 and a 95% confidence interval of 0.79 to 0.91. A comprehensive strategy based on at least 2 out of 3 positive signs showed excellent sensitivity and specificity, and could serve as a non-invasive and fast screening strategy for the clinica
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