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NCT04760106 Date registered on Feb 11, 2021. Prospectively registered. ClinicalTrials.gov no. NCT04760106 Date registered on Feb 11, 2021. Prospectively registered. Researchers have emphasized the importance of examining how different factors affect men's and women's functional status over time. To date, the literature is unclear about whether sex affects the rate of change in disability in middle to older age. Researchers have further emphasized the importance of examining how different factors affect men's and women's functional status