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er for them to acquire more knowledge, and performing screening tests will lead to early diagnosis and lower mortality. This study aimed at modeling the risk of local relapse and death from colorectal cancer after the first treatment and its related factors using multi-state models. In cancer studies modeling the course of disease regarding events which happen to patients is of great importance. By considering death as the final endpoint while incorporating the intermediate events, multi-state models have been developed. This was a histo