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005]. Hemodynamic stability during NIV showed it was better kept in patients treated with butorphanol. Butorphanol not only decreased the requirements of fentanyl but also enhanced hemodynamic stability in agitated patients suffering from ARF receiving NIV. Registered at http//www.chictr.org.cn/ (ChiCTR1800015534). Registered at http//www.chictr.org.cn/ (ChiCTR1800015534). The dysregulation of arrestin domain containing 3 (ARRDC3) has an important effect on oncogenesis and tumor progression in many cancers, including renal cell carcino