https://www.selleckchem.com/pr....oducts/mps1-in-6-com
Background and objectives This article examines a cervical screening incident from the 1960s and draws lessons for screening policy. Study design and setting Concern about harmful overtreatment of symptomless lesions prompted university gynecologist Herbert Green to study, between 1965 and 1970, a 'special series' of 33 women with carcinoma in situ (CIS) who were managed with only limited punch or wedge biopsy. These women were carefully followed up but not treated unless they showed evidence of progression to invasive can
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