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cting CMECs against high glucose-induced damage. Dissipating phlegm and blood stasis simultaneously is better than either of the therapy alone. To explore the role of cell cycle checkpoint kinase 1/2 (CHK1/2) in mediating the inhibitory effect of oxymatrine (OMT) against renal inflammation and fibrosis in diabetic rats. SD rats were randomly divided into normal control group, diabetes model group (DM) and OMT treatment group ( =6). HE and Masson staining were used to observe histopathological changes of the renal tissue, and the exp