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73 [mmHg], 95% confidence interval [CI] 8.68-18.79, = 11.80, 0.001), PaO /FiO (WMD = 38.81 [mmHg], 95% CI 29.85-47.76, = 8.49, = 0.00, and survival time of the deceased patients (WMD = 2.58 [ ], 95% CI 0.97-4.18, = 3.15, = 0.002) compared with usual treatment. Treatment with high doses of ambroxol also appeared to reduce the hospital mortality (relative risk = 0.69, 95% CI 0.55-0.86, Z = 3.25, = 0.001). This study found that high-dose ambroxol is an effective therapy for PQ poisoning and may reduce the in-hospital mortality. This