https://www.selleckchem.com/pr....oducts/GDC-0980-RG74
This study was aimed to investigate the role of Toll-like receptor 4 (TLR4) in advanced glycation end products (AGEs)- induced macrophage polarization toward M1. Isolated primary macrophages were exposed to prepared AGEs at concentrations of 0, 2.5, 5 and 10μmol/L. Macrophages were also exposed to hydrogen peroxide (H O ) which provided exogenous reactive oxygen species (ROS). Receptor for AGEs (RAGE) was over-expressed by a vector. Specific siRNA silencing TLR4 and inhibitor TAK-242 were used to pre-treat the macrophages. Intra
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