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Copyright ©2020, American Association for Cancer Research.The RNA editing core complex (RECC) catalyzes mitochondrial U-insertion/deletion mRNA editing in trypanosomatid flagellates. Some naphthalene-based sulfonated substances, such as C35 and MrB, competitively restrict the auto-adenylylation activity of an essential RECC enzyme, kinetoplastid RNA editing ligase 1 (KREL1), required for the ultimate help editing. Earlier scientific studies disclosed the capability among these compou