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Increased number of cases in Soure, Inhangapi, São João da Ponta and Magalhães Barata, Ponta de Pedras, Breves, Bragança, Castanhal, and São Domingos do Capim were identified in different schedules. Santarém and Belém are the primary foci of leptospirosis as they are more urbanized and densely populated municipalities in the State. The instances present smaller municipalities might be related to periods of more frequent rainfall and blood circulation of Leptospira sp. in marsupials and cattle, in