https://www.selleckchem.com/pr....oducts/CI-1040-(PD18
The expression of exogenous PDE5, a non-photoreceptor-specific member of the PDE superfamily, prevents photoreceptor degeneration in rd1 mice. Unlike endogenous photoreceptor-specific PDE6 that was localised in the outer segments of photoreceptors, ectopically-expressed PDE5 was distributed in inner segments and synaptic terminals. PDE5 also promoted the development of the outer segments in rd1 mice. Co-expression of PDE5 and rhodopsin in cultured cells showed enhanced rhodopsin expression. Lowering the cGMP level in photorec
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