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We show new approaches to developing acoustic liquid sensors based on phononic crystals. The proposed phononic crystal integrates fluidic elements. A solid block with periodic cylindrical holes contains a defect-a liquid-filled cylindrical cavity. We pay attention to acoustic excitation and the readout of the axisymmetric cylindrical resonator eigenmode of the liquid-filled defect in the middle of the phononic crystal structure. This mode solves the challenge of mechanical energy losses due to liquid viscosity. We also analyze the coupl