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act with various aquatic biota in the process. These empirical assessments of particle transport will be valuable for understanding the fate and transformation of microplastic particles in freshwater resources and ultimately contribute to the refinement of global plastic budgets.Valproic acid (VPA) is an efficient antiepileptic drug widely used for the treatment of epilepsy and other seizures in both children and adults. It is also reported to have side and toxic effects on many organs and tissues. Vitamin B6 (Vit B6 ) is a well-describ