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Our findings have added new insights into our understanding of the spatial distribution of genome and disease-related genes across chromosomes. These results could be useful in improving the efficiency of disease-associated gene screening studies by targeting specific chromosomes. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.The absence of efficient mass spectrometry-based approaches for the large-scale analysis of protein arginine methylation has hindered the understanding of its biolo