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SHH-induced cell death didn't take place in the manner of apoptotic signaling paths, while the death structure had been mediated through pyroptosis/necroptosis, which in turn causes membrane layer rupture, development of vacuoles and bleb, activation of caspase-1, and secretion of IL-1β in SHH-treated A549 cells. But, a variety of SHH and colivelin blocked caspase-1 activation. Z-YVAD-FMK and necrostatin-1, pyrotos