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455; OR(C1-=1.849; OR(C2-=1.912). A significant difference in 1G2G genotype frequency was also observed on the basis of two sets of comparisons (P(C-A)0.0005; P(C2-=0.041). The susceptibility of 1G2G genotype carriers to ADDWOR with or without TMJ OA was also considerably higher than that of other genotype carriers (OR(C-A)=2.641; OR(C2-=1.896). The -1607 1G/2G polymorphism of MMP-1 promoter may be related to the susceptibility to ADDWOR with or without TMJ OA. The -1607 1G/2G polymorphism of MMP-1 promoter may be related to