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8% and 48.3%, respectively (P=0.109). Combined modality treatment improved the 3-year OS of all the patients (58.4% vs 33.9%, P=0.001) and 3-year PFS (40.7% vs 20.7%, P=0.008) when compared with chemotherapy alone. LDH elevation, Ann Arbor synthesising and ≥2 junction external bits were intrusive as independent risk factors for total survival (P less then 0.05), LDH elevation and ≥2 junction outer bits were intrusive as independent risk factors for progressionless survival(P less then 0.05). The distant extranodal dissemination was the