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Both numerical simulations and phantom experiments are established to validate the proposed method. RESULTS Compared with the results without consideration of the variation on acoustic speed, sound sources reconstructed by our method are more consistent with the model in terms of size and shape. CONCLUSIONS The novel algorithm can be used to reconstruct the high accuracy image of MAT-MI sound source in the sound velocity inhomogeneous media. In addition, this method is applicable to scenarios that the prior knowledge of the imaging tar