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82, 95% CI 1.04-3.20, = 0.037). There were no significant differences between the treatment groups with the ulcer reduction rate. Evidences now available show rebamipide plus PPIs is practical for protecting against ESD-induced ulcers at four weeks but not at eight weeks, especially large ulcers (20 mm). However, we still need more high-quality RCTs in the future to supplement our conclusions. 20 mm). However, we still need more high-quality RCTs in the future to supplement our conclusions.We successfully extracted isoliquiritigenin