https://www.selleckchem.com/pr....oducts/taurocholic-a
The tumorigenesis of NPC cells overexpressing ACAT1 was decreased in vivo. Elevated ACAT1 in NPC cells was accompanied by an elevated expression of CDH1 and a reduced expression of vimentin and SPARC, strongly indicating that ACAT1 is involved in regulating epithelial-mesenchymal transition (EMT). We also found that ACAT1 contributes to increased intracellular levels of β-hydroxybutyrate (β-H. Exogenously supplied β-HB significantly inhibits the growth of NPC cells in a dose-dependent manner. In summary, A
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